Development of active icosahedron and its application to virtual clay modeling

We have developed an active link mechanism for physical man-machine interaction. We report an active icosahedron consisting of intelligent cylinders and its application to virtual clay modeling. Intelligent pneumatic cylinders are newly developed to realize active link mechanisms. This cylinder aims at a novel cylinder in which various sensors and control devices are built. Active link mechanisms are highly integrated and enhanced by intelligent cylinders. A control system is built for the active icosahedron. In the control system, a key element is a control program implementing drawing of a virtual model on display and controlling of active links. Virtual clays are deformed by the program based on the apex positions converted from cylinder lengths. The active icosahedron realized dynamic interaction with virtual objects in PC, showing the potential of the devices as a haptic interface.</p

Refrex-1, a soluble restriction factor against feline endogenous and exogenous retroviruses

The host defense against viral infection is acquired during the coevolution or symbiosis of the host and pathogen. Several cellular factors that restrict retroviral infection have been identified in the hosts. Feline leukemia virus (FeLV) is a gammaretrovirus that is classified into several receptor interference groups, including a novel FeLV-subgroup D (FeLV-D) that we recently identified. FeLV-D is generated by transduction of the env gene of feline endogenous gammaretrovirus of the domestic cat (ERV-DCs) into FeLV. Some ERV-DCs are replication competent viruses which are present and hereditary in cats. We report here the determination of new viral receptor interference groups and the discovery of a soluble antiretroviral factor, termed Refrex-1. Detailed analysis of FeLV-D strains and ERV-DCs showed two receptor interference groups that are distinct from other FeLV subgroups, and Refrex-1 specifically inhibited one of them. Refrex-1 is characterized as a truncated envelope protein of ERV-DC and includes the N-terminal region of surface unit, which is a putative receptor-binding domain, but lacks the transmembrane region. Refrex-1 is efficiently secreted from the cells and appears to cause receptor interference extracellularly. Two variants of Refrex-1 encoded by provirus loci, ERV-DC7 and DC16, are expressed in a broad range of feline tissues. The host retains Refrex-1 as an antiretroviral factor, which may potentially prevent reemergence of the ERVs and the emergence of novel ERV-related viruses in cats. Refrex-1 may have been acquired during endogenization of ERV-DCs and may play an important role in retroviral restriction and antiviral defense in cats